Thursday, December 16, 2021

Herrera presents renal pathology research at international meeting

Guillermo Herrera, M.D., professor and chair of pathology at the USA College of Medicine, recently presented at a symposium on AL-amyloidosis in the kidney for the American Society of Nephrology Kidney Week 2021. More than 10,000 nephrologists, pathologists and basic science researchers attended the virtual meeting.

He presented on “Fibril Generation in Amyloidosis: Potential for Therapeutic Interruption.” In the session he discussed new opportunities for therapeutically preventing, interrupting and reversing amyloid deposition in the kidney and other organs. 

Other members of the research team responsible for the findings included Jiamin Teng, M.D., Ph.D., associate professor of pathology; Elba Turbat-Herrera, M.D., professor of pathology; Luis del Pozo-Yauner, M.D., Ph.D., assistant professor of pathology; and Chun Zeng, Ph.D., research associate in pathology.

Herrera earned his medical degree from the University of Puerto Rico School of Medicine in San Juan. He completed his residency training in anatomic and clinical pathology at Brooke Army Medical Center in San Antonio, Texas. He is certified by the American Board of Pathology in anatomic and clinical pathology and cytopathology. 

More than 75 children assisted by medical students during Saturday health camp

Medical students, residents and attending physicians volunteer at the pediatric health camp.
Nearly 80 children took part in a free pediatric health camp on Saturday, Dec. 4, hosted by the USA Health Pediatric Residency Diversity Coalition at Cody Road Seventh-day Adventist Church.

USA College of Medicine students, along with resident physicians, attendings and faculty members, took part in the event aimed at Spanish-speaking members of the community.

“The medical students were a key component of the community outreach,” said Renee Roca, M.D., an assistant professor of pediatrics at the USA College of Medicine and a hospitalist at Children’s & Women’s Hospital.

More than 20 medical students volunteered their time during the Saturday initiative to help with everything from anthropometric screening, vision screening, developmental screenings, health education including dental hygiene, car seat safety, water safety, safe sleep and vaccinations.

The event was held in partnership with Ascension Providence Guadalupe Center and the USA Regional Autism Network (RAN).

View more photos from the event on Flickr

Medical student completes prestigious rheumatology preceptorship

Emily Polhill, a second-year medical student at the USA College of Medicine, earned a sought-after medical student preceptorship from the Rheumatology Research Foundation. She recently was recognized as one of the recipients at the American College of Rheumatology national meeting, held virtually in early November. 

Awarded to only 30 medical and graduate students each year, the $4,000 grant provided financial support for Polhill to complete a preceptorship in rheumatology. Preceptorships encourage students to learn more about rheumatology and pursue careers in the field by supporting a one-on-one, real-world learning experience.  

A native of Birmingham, Polhill worked with pediatric rheumatologist Melissa Mannion, M.D., of the University of Alabama at Birmingham. During her preceptorship, she studied qualitative analysis and coding of interviews for pediatric rheumatology groups. The goal of her research was to understand the differences in institutional context that may influence the quality of care delivered to children with juvenile idiopathic arthritis.

This past summer, Polhill shadowed Mannion at Camp MASH, or Make Arthritis Stop Hurting, a camp for children ages 7 to 17 with a form of juvenile arthritis or a related auto-immune disease. Mannion encouraged Polhill to apply for the preceptorship award through the Rheumatology Research Foundation.

A graduate of Brigham Young University, Polhill said she is grateful for the experience and knowledge she gained through the preceptorship.

Cancer researchers at MCI receive BCRFA funding

Three cancer researchers at the USA Health Mitchell Cancer Institute have received grants from the Breast Cancer Research Foundation of Alabama as part of the organization’s $1.2 million investment in state-based research in 2021.

The recipients of the three awards, totaling almost $110,000, include Robert W. Sobol, Ph.D., professor of pharmacology; Lyudmila Rachek, Ph.D., assistant professor of pharmacology; and Santanu Dasgupta, Ph.D., assistant professor of pathology at the USA College of Medicine.

BCRFA grants often act as seed funding for developing studies, allowing scientists to generate data needed to obtain major national funding.

Sobol will use a $50,000 BCRFA grant to expand his study of a new treatment combination targeting breast cancer that is resistant to therapy. The treatment combines a PARG inhibitor, a compound that keeps the enzyme PARG from enabling tumor cells to replicate, with small molecules to regulate cellular NAD+ levels, developed by Marie E. Migaud, Ph.D. Sobol will test the combination treatment and the PARG inhibitor alone in breast cancer cell lines and normal breast cells.

“Our goal will be to expand our analysis to a large panel of breast cancer and breast normal cells, eventually allowing strategic targeting to breast cancers with this combination treatment,” he said.

Rachek and her team will use a $35,000 grant for a one-year project to elucidate the protective mechanisms of mitochondrial delivery of TAT-hOGG1 in breast cancer progression. For this, they will perform gene expression analysis in mouse breast cancer models with mitochondrial-targeted TAT-hOGG1 using RNA sequencing.

“This study has important clinical and translational significance and will provide the basis for new unconventional therapeutic approaches for treating breast cancer,” Rachek said. “This project is particularly timely given the lack of available effective therapies and prognosis for patients with advanced breast cancer. We are very grateful to the BCRFA for providing us the opportunity to continue translational research.”

Santanu Dasgupta, Ph.D., is using his BCRFA grant to investigate mitochondrial genome alterations in women suffering from triple negative breast cancer with a view to develop mitochondria-based early diagnosis and surveillance tools.

“Early detection of this lethal disease can save lives with available treatments,” Dasgupta said. “This grant will serve as the platform to generate clinically relevant data and open up avenues for comprehensive profiling of the mitochondrial genome in these women.”

Wednesday, December 15, 2021

USA College of Medicine establishes Black Men in White Coats affiliate chapter

Warren Law III, a first-year medical student, and Trentyn Shaw, a second-year medical student, are vice president and president, respectively, of the USA College of Medicine's affiliate chapter of Black Men in White Coats.
Only 2 percent of American doctors are Black men. Black men also have the lowest life expectancy of any major demographic group in the United States. 

This correlation comes as no surprise to Johnson Haynes Jr., M.D., assistant dean of diversity and inclusion and professor of internal medicine at the USA College of Medicine. 

He asks: “What if we had a medical workforce that actually reflected our patient population? What’s happening in society that more Black women are becoming doctors while Black men are stagnant?”

With the goal of increasing the number of Black men in the field of medicine, the USA College of Medicine has established an affiliate chapter of Black Men in White Coats. Mirroring the national organization’s mission, the local chapter seeks to accomplish this objective through exposure, inspiration and mentorship.

“Efforts such as this seek to dissect the systemic barriers preventing Black men from becoming medical doctors and the consequences on society at large,” said Haynes, who is the faculty sponsor for the new chapter. “Healthcare accounts for nearly 20 percent of the United States GDP, and a significant portion of that is driven by disparities in a system that lacks diverse physicians.” 

Second-year medical student Trentyn Shaw serves as the USA College of Medicine affiliate chapter’s president. “Representation: a single word that holds so much weight. Accomplishing one's dream is a scary task on its own, but doing it alone can make it that much harder,” he said. “Being an example for young Black men who aspire to be physicians is something crucial. Having representation shows that their dreams are capable of being accomplished, and we are living proof that it is.”

Shaw said his aim as president is to help lead and build the chapter into one that will serve and mentor the community, “ushering in a new and bigger wave of Black doctors.”

Warren Law III, a first-year medical student and the chapter’s vice president, echoed Shaw’s goals for the organization. “Becoming a Black male physician may be difficult to imagine for Black men, because it is highly likely that they have never seen one before. Put simply, it is difficult to ‘be’ what you can’t ‘see,’” he said. “What I hope to accomplish as vice president of BMWC, is to afford young learners the ability to see what they very well can become.” 

The USA College of Medicine’s affiliate chapter of Black Men in White Coats seeks members who are enrolled in, or have graduated from, professional school (medical, dental, veterinary or other health professions). 

Chapter meetings will be held at least once every three months with the purpose of supporting one another and to plan activities that focus on exposing Black youth (boys and young men) to medicine and providing them with mentorship. 

Through quarterly school visits, whether virtual or in-person, Haynes said the chapter plans to connect with local schools in partnership with the USA College of Medicine’s Office of Diversity and Inclusion. 

In March, the USA College of Medicine hosted a virtual screening of the documentary “Black Men In White Coats,” followed by a panel discussion led by Black male physicians and medical students. 

Contact Johnson Haynes Jr., M.D., at 251-341-4072 or jhaynes@health.southalabama.edu to join the USA College of Medicine’s affiliate chapter. 

Learn more about Black Men in White Coats

Scalici awarded 2021 Mayer Mitchell Award for Excellence in Cancer Research

Physician-scientist Jennifer M. Scalici, M.D., has been named the recipient of the 2021 Mayer Mitchell Award for Excellence in Cancer Research.

Scalici, chief of gynecologic oncology service at the USA Health Mitchell Cancer Institute and a professor of gynecologic oncology at the USA College of Medicine, directs MCI’s gynecologic oncology research.

Martin Heslin, M.D., director of the Mitchell Cancer
Institute, and Arlene Mitchell present the award to
Jennifer Scalici, M.D.
The $10,000 award is presented annually to a promising scientist at the Mitchell Cancer Institute upon the recommendation of a faculty committee. The award was established in 2009 by University of South Alabama Trustee Arlene Mitchell in memory of her late husband, Mayer Mitchell, a Mobile businessman, longtime USA trustee and formative figure in the establishment of the MCI.

Since joining the MCI in 2012, Scalici has focused her collaborative research on ovarian cancer carcinogenesis and chemo-prevention as well as the active DNA damage and repair mechanisms, and metabolic changes underlying gynecologic cancers.

Supported by grant funding from the U.S. Department of Defense, including a recent $450,000 award, she has led collaborations with Auburn University and the University of Virginia as she continues to examine the effectiveness of a novel compound, developed in-house at the MCI, for the prevention of ovarian cancer. Scalici also serves on numerous national committees focused on advancing the science and developing new clinical trials to advance the treatment of gynecologic cancers.

In addition, Scalici has built a clinical practice emphasizing evidence-based care and advanced surgical techniques for gynecologic malignancies. She served as site principal investigator for a clinical trial that brought fluorescent sentinel lymph node dissection in endometrial cancer to Mobile, a technique that has become integrated into the standard of care nationally.

“As a physician-scientist, Dr. Scalici fully understands the plight of women who are suffering from GYN cancers. She brings that unique understanding to the research lab, where she and her team continue to lead promising projects,” said John V. Marymont, M.D., M.B.A., vice president for medical affairs and dean of the USA College of Medicine. “She is very deserving of this honor.”

Scalici earned her medical degree from the University of Alabama at Birmingham. She completed a residency in obstetrics and gynecology at Northwestern University McGraw Medical Center in Chicago and a fellowship in gynecologic oncology at the University of Virginia Health System in Charlottesville, Va.

Meet a Med Student: Kayman Strickland-Beach

Kayman Strickland-Beach

Age: 23

Class of: 2024

Hometown: Homewood, Ala.

Undergrad/grad institution: University of South Alabama

Degrees earned: Bachelor of Science in biomedical sciences

Interests/hobbies: Traveling, entertaining my two huskies and coffee with friends.

Something unique about me: I am the first in my family to pursue a career as a physician.

Three of my favorite things: My husband, my kids (two foster kids and the newest addition born on Nov. 9) and my huskies.

What I enjoy most about being a student at the College of Medicine: The community of classmates and faculty is one of a kind. They truly support you as an individual and do all they can to help you thrive not only in your studies, but in all areas of your life.



Thursday, December 9, 2021

Grelet to present on breast cancer neurogenesis at Pathology Research Symposium

Simon Grelet, Ph.D., assistant professor of biochemistry and molecular biology at the USA College of Medicine and a cancer researcher at the Mitchell Cancer Institute, is December's guest lecturer for the Pathology Research Symposium series. 

He will present "Plasticity-mediated breast cancer neurogenesis" at noon on Thursday, Dec. 16, in the Strada Patient Care Center conference room. 

Grelet joined the faculty in December 2020. His research focuses on the function of tumor neurogenesis in cancer progression and metastasis.

For more information, contact Patrick Carlisle at 251-471-7753 or pcarlisle@health.southalabama.edu.

Randall W. Powell Endowed Memorial Lectures set for Dec. 16-17

The 2021 Randall W. Powell Endowed Memorial Lectureship in Pediatric Surgery, hosted by the USA Department of Surgery, will feature Doruk Ozgediz, M.D., M.S.C., director of the Center of Global Surgery and Health Equity and associate professor of pediatric surgery at the University of California San Francisco.

Ozgediz will present the first lecture, “Surgical Pearls and Pitfalls: Lessons in Partnerships to Serve Vulnerable Populations Globally” on Thursday, Dec. 16, at 4:30 p.m. via Zoom: https://southalabama.zoom.us/j/96457019824

His second lecture, titled “Global Surgery 2021: Where are we now and where are we going?” is set for Friday, Dec. 17, at 7 a.m. via Zoom: https://southalabama.zoom.us/j/96457019824.

The lectureship is named in honor of the late Randall W. Powell, M.D., former professor of surgery at the USA College of Medicine and director of the division of pediatric surgery, who passed away in 2017. 

Both lectures are CME accredited. For more information, contact the USA Department of Surgery at 251-445-8230.

Faculty Spotlight: Jess Mullens, M.D.


Jess Mullens, M.D.

Academic title: Assistant professor of orthopaedic surgery, foot and ankle

Joined the USA College of Medicine faculty: November 2021

What does your position in the USA COM/USA Health entail?
My position within the Department of Orthopaedic Surgery entails treatment of orthopaedic foot and ankle problems which includes fractures, ligament and tendon injuries, foot deformity and complex reconstruction, as well as diabetic foot care. I take part in research and teach residents and medical students on my service.

What is your favorite or most rewarding part of your position?
My favorite part of my position is the opportunity to work with residents and medical students to teach all aspects of the foot and ankle. I believe it is important to be able to share what you are passionate about and to show others how to get back on their feet again.

What research or other initiatives are you involved in?
I have an interest in research specifically in the fields of wound healing and functional outcomes for common foot and ankle procedures. I hope to partner with other surgical divisions in developing a comprehensive wound care center.

What is your advice for medical/basic medical sciences students?
My advice for students is to always keep an open mind about what lies ahead in your future. It’s important to study the material to truly learn it. Don’t study just to get to the next step. Find mentors who will spend time with you and share their knowledge because that’s how you find your career. From the time I started medical school until the time I ended residency, my career path must have changed at least a dozen times. And looking back, it was my mentors who helped pave the way to where I am now.

What are your hobbies/interests outside of work?
I enjoy spending time with my wife and two children in Orange Beach. I like to play basketball and stay active. I enjoy taking trips with my family, watching movies and reading a good book.



Meet a Med Student: Daniel Irelan

Daniel Irelan

Age: 27

Class of: 2024

Hometown: Huntsville, Ala.

Undergrad/grad institution: University of South Alabama

Degrees earned: Bachelor of Science in biomedical sciences

Interests, hobbies: Cyclic-AMP signaling in Obesity/Metabolic Syndrome, guitar, video games and hanging out with my significant other.

Something unique about me: I saw my life flash before my eyes when I got too close to a bison at Yellowstone National Park.

Three of my favorite things: My “triple therapy”: Gevalia coffee, Coke Zero (+/- cherry), and food.

What I enjoy most about being a student at the USA College of Medicine: The USA COM provides a top-tier M.D. program while giving students access to the resources needed to further their research interests.



Monday, December 6, 2021

Band registration open for Doc Rock fundraising event

Calling all band members: Registration is open for USA Health's new "battle of the bands" event, Doc Rock!  

Join us March 31, 2022, at Soul Kitchen in downtown Mobile for the inaugural event benefiting research and critical clinical needs at USA Health Mitchell Cancer Institute, Children’s & Women’s Hospital and University Hospital. Attendees will have the opportunity to vote for their favorite band, and prizes will be awarded in four categories. 

All music styles are welcome. At least one member of each band must have an affiliation with USA Health or the USA College of Medicine.

Band registration ends Jan. 3, 2022, at 11:59 p.m. Tickets for admission to the show will go on sale in January.

Learn more at www.usahealthsystem.com/doc-rock

Cancer and DNA damage: Discovery by USA scientists may improve patient outcomes

Robert W. Sobol, Ph.D., professor of pharmacology, and Christopher A. Koczor, Ph.D., instructor of pharmacology, are studying genes and other factors that cause cancer. 
A discovery made by USA College of Medicine scientists may provide further understanding of genes and factors that cause cancer, its relation to DNA damage and provide better treatment options for patients. 

An article about the discovery recently was published in the scientific journal Cell Reports. It explores how the human genome constantly is damaged by environmental and cellular products, which could lead to cancer if not properly repaired. The study also delves into treatments for DNA damage and repair. The article, written by Robert W. Sobol, Ph.D., professor of pharmacology at the USA College of Medicine and chief of the Molecular and Metabolic Oncology Program at the Mitchell Cancer Institute (MCI), and co-authors, appeared in the October 2021 issue.

Genomes, comprised of DNA, are a complete set of genetic instructions. Each genome contains all the information needed to build an organism and allow it to grow and develop. It is critical for cells to keep the genome intact. This is the main function of more than 200 genes that are part of the cellular pathways governing DNA damage and repair. 

One cellular pathway, the base excision repair pathway, monitors the genome for small DNA lesions and repairs it if needed. This process occurs close to 20,000 times per cell, per day. Failure to repair these lesions could lead to mutations that could cause cancer. Several proteins that control the base excision repair pathway, known as poly (ADP-ribose) polymerase 1 (PARP1) and poly (ADP-ribose) polymerase 2 (PARP2), are targets for drugs used to treat cancer. 

The goal of the study is to learn more about these critical proteins and how they respond to DNA damage. 

“This breakthrough research uses state-of-the-art microscopy and genetic techniques to follow the movement of key base excision repair pathways and their response to damage, which could be beneficial for patients,” said Sobol. “Future studies can build on this discovery as we continuously work to identify additional genes and factors that are defective or that may be considered biomarkers of response related to cancer.” 

The Molecular and Metabolic Oncology Program at the Mitchell Cancer Institute focuses on the cellular mechanisms of DNA repair and metabolism and how these processes impact cancer development and the response to cancer treatments.

Study co-authors from the USA College of Medicine and the MCI include Christopher A. Koczor, Ph.D., instructor of pharmacology; Jennifer Clark, Ph.D., instructor of pharmacology; Marie E. Migaud, Ph.D., professor of pharmacology; Jianfeng Li, Ph.D., assistant professor of pharmacology; Joel F. Andrews, Ph.D., manager of the MCI Cellular and Biomolecular Imaging Facility; Steve McClellan, manager of the MCI Flow Cytometry Facility; Qingming Fang, Ph.D., assistant professor of pharmacology; and Kate Saville, Md Ibrahim and Rasha Al-Rahahleh, USA College of Medicine graduate students.

Read the full article in Cell Reports

Thursday, December 2, 2021

Volunteer opportunity: pediatric health camp on Saturday, Dec. 4

Students, faculty and staff are needed to volunteer this Saturday, Dec. 4, to help with a pediatric health camp from 9 a.m. to 1 p.m. at Cody Road Seventh-Day Adventist Church, 1900 Cody Road in Mobile.

Those who take part will be asked to help with the various stations at the health camp. Although this event caters to the Spanish-speaking population, volunteers do not need to speak Spanish to participate, organizers said. 

The health camp is sponsored by the Pediatric Residency Program Diversity Coalition in partnership with the Ascension Providence Guadalupe Center and the USA Regional Autism Network.

For more information, contact Renee Roca, M.D., at mrrocagarcia@health.southalabama.edu or Swati John, M.D., at sjohn@health.southalabama.edu.

Pathologist discusses cancer molecular profiling at national meeting

Thuy Phung, M.D., Ph.D., medical director of molecular pathology and dermatopathology at USA Health, is spreading the word about USA Health’s in-house molecular profiling program for cancer treatment.

Phung, who also is an associate professor of pathology at the USA College of Medicine, recently presented a workshop at the Association for Molecular Pathology (AMP) annual conference. She discussed the requirements for successful set-up and implementation of cancer molecular profiling at USA Health.

Molecular profiling quickly is becoming a critical tool in identifying genomic mutations that indicate a potential response to targeted cancer therapy. USA Health has partnered with Vancouver-based Canexia Health to bring oncology molecular capabilities in-house.

During the interactive virtual workshop, hosted by Canexia Health, Phung discussed how faster turnaround time and better management of patient data were among the advantages, as well as improved access to clinical trials, which enables precision oncology to be broadly accessible within community practices where most cancer patients are treated.

“I think we have put USA Health on the map in the molecular diagnostic world,” Phung said. “Some AMP attendees have already reached out to me about building their own in-house testing.”

The Association for Molecular Pathology advances the clinical practice, science and excellence of molecular and genomic laboratory medicine through education, innovation and advocacy. The society’s more than 2,500 members include pathologists, clinical laboratory scientists, technologists and clinicians.

Medical students collect 60 gift boxes for children in need

Second-year medical students Jessie Moore
and Rachel Emig coordinated an Operation
Christmas Child campaign.
A gift box campaign organized by two second-year medical students at the USA College of Medicine is sending 60 gifts to children around the world during the holidays.

Earlier this fall, Jessie Moore of Huntsville and Rachel Emig of Tuscaloosa coordinated an Operation Christmas Child campaign and invited faculty and fellow students to participate. The project is affiliated with Samaritan’s Purse, a faith-based relief organization.

Within weeks, donors contributed 60 shoeboxes filled with necessities and toys, and the students took them to a distribution site for delivery.

“We prayed for 25 boxes, and the Lord blessed this project greater than we could have imagined,” Moore said. “We would like to thank the staff and students at the College of Medicine, including the Christian Medical Ministry of South Alabama and the Pediatric Interest Group as our sponsors, along with family and friends. There will be some extremely excited children this Christmas season and into next year.”

Moore and Emig, who became friends as undergraduates at Mississippi State University, said they grew up participating in Operation Christmas Child at their hometown churches. “It is a tangible way to demonstrate God’s love to kids around the world,” Moore said.

Wednesday, December 1, 2021

Meet a Med Student: Brenna Katz

Brenna Katz

Age: 24

Class of: 2024

Hometown: Montgomery, Ala.

Undergrad/grad institution: Rhodes College

Degrees earned: Bachelor of Science in biology

Interests, hobbies: Binge watching the latest Netflix show, running and working out outdoors, and golfing.

Something unique about me: I have been to six music festivals, and I have run a marathon.

Three of my favorite things: Spending time with my family and friends at the lake, taking a long nap on a rainy day, and putting together charcuterie boards with friends.

What I enjoy most about being a student at the USA College of Medicine: I enjoy how much the faculty cares about each individual student.



Monday, November 29, 2021

Faculty Spotlight: Tyler McDonald, M.D.

Tyler McDonald, M.D.

Academic title: Assistant professor of orthopaedic surgery

Joined the USA College of Medicine faculty: September 2021

What does your position in the USA COM/USA Health entail? 
As a pediatric orthopaedic surgeon, I specialize in all aspects of orthopaedic care for children and adolescents including spine care. I see patients in the clinic, teach residents in the orthopaedic surgery residency program and perform orthopaedic surgeries.

What is your favorite or most rewarding part of your position?
Helping a child regain their function to get them playing and being a kid again.

What research or other initiatives are you involved in?
Many of my research interests involve pediatric spine pathology, such as idiopathic, neuromuscular and congenital scoliosis in children.

What is your advice for medical/basic medical sciences students?
Keep your options open and let your heart guide you. I thought I wanted to be a joint replacement surgeon until midway through residency when I started working more with kids. I knew I was called to help children.

What are your hobbies/interests outside of work?
Fly fishing and woodworking. When I’m not at work you can probably find me building something in my garage “workshop.”



Pathology resumes monthly research symposium

Bing Wang, M.D., Ph.D., from the University of Pittsburgh School of Medicine presents at the Pathology Research Symposium.
The USA Department of Pathology announces the return of the Pathology Research Symposium. Presentations will be held at noon on the third Thursday of every month at the Strada Patient Care Center. 

From left, Guillermo Herrera, M.D., professor and chair
of pathology; presenter Bing Wang, M.D., Ph.D.; and
Ajay Singh, Ph.D., professor of pathology.
The first presenter on Nov. 18 was Bing Wang, M.D., Ph.D., an associate professor at the University of Pittsburgh School of Medicine’s McGowan Institute for Regenerative Medicine and the University of Pittsburgh’s Vascular Medicine Institute. He discussed gene therapy combining tissue engineering for musculoskeletal regeneration. 

The Department of Pathology welcomes participation from all interested parties and individuals. For more information, contact the department at 251-471-7753 or pcarlisle@health.southalabama.edu.

Thursday, November 18, 2021

Medical student chosen for national AAMC advisory task force

Veena Krishnan, a third-year student at the USA College of Medicine, is among the medical students and residents selected to serve on a nationwide advisory task force for the Association of American Medical Colleges' CLASS Project.

The purpose of the CLASS Project, which stands for Clinical Skills Assessment and Standardization, is to aid in developing new practices and national standards that will properly assess clinical skills in medical education. Previously, medical schools used Step 2 CS of the United States Medical Licensure Exam to assess whether their students were prepared for residency. Step 2 was discontinued permanently in January 2021. The task force will work to determine a national standard for equitable, effective and appropriate clinical skills education.

“It is a great honor and privilege to be chosen to represent the USA COM’s voice on the national stage about this important issue,” said Krishnan. “I look forward to learning from some of the most knowledgeable voices in academic medicine and participating in a process that strives to make medical education more inclusive.”

More than 500 people were nominated for the task force, with more than 100 of those consisting of student and resident nominees across the United States. Krishnan’s selection to join this group provides an opportunity for her to contribute to the development of clinical skills educational guidelines that will be implemented nationwide.

Foot and ankle surgeon joins Department of Orthopaedic Surgery

USA Health’s Department of Orthopaedic Surgery expands with the addition of Jess Mullens, M.D., a foot and ankle orthopaedic surgeon.

Mullens will treat patients for conditions including sports injuries, foot and ankle fractures, ligament and tendon problems, and arthritis.

He pursued orthopaedic surgery and the foot and ankle specialty because of personal and family issues.

“My grandmother suffered from Type 2 diabetes and developed several foot wounds, and I helped care for her, which led to my interest,” Mullens said. “In college, I played basketball, which led to my own foot and ankle injuries. My experiences give me a unique perspective for athletes wanting to return to performing at a high level.”

Mullens said he always was drawn to surgery and wanted to be a part of the process.

“The interactions with other surgeons, anesthesiologists, nurses, techs and staff was a unique experience within the operating room,” he said. “I was drawn to the way bones, muscles, tendons and ligaments work together to provide people the ability to walk, run and perform activities. I wanted to be a part of a specialty that could help those who had lost the ability to do the activities they love.”

While working in an academic health system, Mullens, an assistant professor of orthopaedic surgery, wants to broaden the study of the foot and ankle specialty.

“I would like to participate and lead more foot and ankle research, particularly in the areas of diabetic foot care and sports-related foot and ankle injuries,” he said. “I believe that resident and medical student education is the most important part of being on the faculty at USA. I am excited to be able to teach, mentor and encourage others to pursue a future in foot and ankle orthopaedics.”

Mullens earned a medical degree from the University of Alabama at Birmingham School of Medicine in Birmingham. He completed a residency in orthopaedic surgery at the USA College of Medicine and a fellowship in the foot and ankle specialty at The Steadman Clinic at Vail Health Hospital in Vail, Colorado.

Mullens sees patients on the third floor of the Strada Patient Care Center in Mobile. To make an appointment, call (251) 665-8200.

Tuesday, November 16, 2021

Video online: 'Skull Base Neurosurgery and Brain Tumors'

Jai Thakur, M.D., director of minimally invasive cranial and skull base neurosurgery and neurosurgery education at USA Health, presented “Skull Base Neurosurgery and Brain Tumors: Rejecting Norms and Adapting Minimally Invasive Mentality” at the Med School Café lecture on Nov. 12.

Watch a video of the presentation on YouTube.


Nicotine weakens immune system, USA researchers find

Srijan Acharya, Ph.D., a postdoctoral research fellow, and
Sirin Saranyutanon, a Ph.D. candidate in the Basic Medical
Sciences Graduate Program, study the effect of nicotine
at the Mitchell Cancer Institute.
Scientists at the USA College of Medicine and the USA Health Mitchell Cancer Institute found that nicotine, the addictive ingredient in tobacco products and cigarette substitutes, plays a novel role in immunosuppression. The findings highlight the health hazards of nicotine intake including an enhanced susceptibility to developing cancer.

As part of her doctoral research project, Sirin Saranyutanon, a Ph.D. candidate in the Basic Medical Sciences Graduate Program, investigated the effect of nicotine on macrophage polarization, growth and invasion to understand its role in human physiology. Macrophages are an important component of the innate immune system that can have both pro- and anti-inflammatory functions depending upon their polarization state.

“Our findings suggest that nicotine weakens our immune system by altering the function of macrophages, and converting them from defenders to the type that helps resolve protective inflammatory response and support tumor growth,” Saranyutanon said.

The findings add to the growing concern about the use of nicotine, said Ajay Singh, Ph.D., who is the advisor of Saranyutanon and a professor of pathology at the College of Medicine and leader of the Cancer Biology Program at the Mitchell Cancer Institute. 

“The use of nicotine through vaping has increased tremendously in recent years, especially among teens, owing to the belief that it’s less damaging than smoking,” Singh said. “Moreover, vaping products are cheaper and available in tempting flavors. Being a relatively newer trend, epidemiological data associating vaping with slow-developing diseases like cancer is not yet available. However, our findings should raise awareness about the harms that it can cause to human health.”

The study was published in the Journal of Cellular Physiology, a high-impact journal that publishes research on eukaryotic cell biology and physiology. Authors include researchers from the College of Medicine and the Mitchell Cancer Institute: Srijan Acharya, Ph.D., postdoctoral research fellow; Sachin Kumar Deshmukh, Ph.D., research associate; Mohammad Aslam Khan, Ph.D., research associate; Seema Singh, Ph.D., professor of pathology; and Ajay Singh, Ph.D.

As a doctoral student at the USA College of Medicine, Saranyutanon said she has felt both challenged and supported in her research. “I have had the opportunity to interact with incredible scientists in my field, and I am always learning and growing from my interactions with faculty, postdocs, academic advisors and fellow students,” she said. 

Saranyutanon said research can be stressful at times but ultimately is very rewarding. “When you discover something new and it gets recognized, the feeling is undefinable,” she said. “You become part of scientific advances that eventually contribute to a better, longer and disease-free life.”

Read the full article in the Journal of Cellular Physiology.

Friday, November 12, 2021

In Memoriam: Henry Mullins Jr., M.D., served as first chair of family medicine

Henry Clifford Mullins Jr., M.D., the first chair of family medicine at the University of South Alabama College of Medicine, died Nov. 9, 2021. Mullins was instrumental in establishing the department and served as professor and chair for 16 years. 

“I considered Dr. Mullins a mentor and friend,” said Allen Perkins, M.D., M.P.H., professor and chair of family medicine. “He was well ahead of his time as an educator and was a pioneer in distance education. The leadership and guidance that he modeled have continued to inspire me to this day. He will be missed.”

Mullins earned his medical degree from Tulane University School of Medicine in New Orleans. From 1954 to 1956, he served as a U.S. Army physician and was stationed in Tehran, Iran. 

A resident of Fairhope, Mullins was a family physician in private practice for many years. He was a trailblazer in emerging medical technologies, traveling the world with colleagues from England and Australia espousing the value of electronic medical record systems decades before they became widely accepted. 

Nationally, Mullins consulted with the National Institutes of Health and Crozer-Keystone Health Systems. Locally, he helped found the South West Alabama Abuse Network (SWAAN) that established remote examinations of child sexual abuse victims in rural Alabama. 

He served in numerous local, state and national leadership positions with the Baldwin County Medical Society, the Medical Association of Alabama, and the American Academy of Family Physicians.

Despite all of these achievements, Mullins would be most proud to be referred to as a “country doctor.” 

Read his full obituary on al.com.

Thursday, November 11, 2021

USA Health launches in-house molecular cancer tests to guide precision medicine

The Molecular Pathology Laboratory staff, from left, are Thuy Phung, M.D., Ph.D.; John Larrimore, M.B., Kathryn Navia, M.T.; and Doug Hebert, Ph.D.
USA Health now offers two in-house molecular oncology tests for cancer patients – BRAF Gene Mutation Assay and MSI (Microsatellite Instability) Assay. Onsite testing means patients receive results more quickly and can start the appropriate treatment sooner than if an outside laboratory performs the testing.

“The Molecular Pathology Laboratory at USA Health – the first precision oncology lab in the area – provides much-needed molecular testing services for patients in our local region by performing onsite, in-house cancer tests,” said Thuy Phung, M.D., Ph.D., associate professor of pathology at the USA College of Medicine and medical director of molecular pathology and dermatopathology at USA Health. “This will significantly accelerate the diagnostic process and enable physicians to make critical therapy decisions for patients in a timely manner.”

Doug Hebert, Ph.D., lead molecular medical scientist,
prepares a sample for testing.
Previously, USA Health sent specimens to outside reference labs for BRAF mutation and MSI tests, with turnaround time of results to patients taking several weeks. The tests are now implemented at USA Health. They are fully automated and can detect mutations directly from tumor tissue and cytology specimens. Clinicians typically receive results within a few business days from the time a specimen is received in the molecular lab for testing.

The most common mutations in BRAF gene occur in codon 600 and are found in approximately 50 percent of melanoma patients. BRAF mutations also are harbored in a variety of other solid tumors including colorectal, endometrial, lung and blood cancers. Several therapies have been developed that target BRAF codon 600 mutations and have shown clinical response rates in up to half of patients with metastatic melanoma. Testing for gene mutations is critical in determining how to tailor treatment for each patient in the current era of precision medicine and oncology care.

The MSI Assay detects biomarkers for cancers with microsatellite instability, including colorectal and endometrial cancer. Determining MSI status is a screening test for Lynch Syndrome, an inherited disorder that increases the risk of developing colorectal cancer, endometrial cancer and several other solid tumor types. MSI status also serves as a predictive biomarker for response to immunotherapy with immune checkpoint inhibitors.

The lab is now working on expanding the current test menu to include other key molecular biomarkers as well as bringing in state-of the-art next generation sequencing (NGS)-based assays to uncover key mutations for targeted therapy in a variety of common cancers.

As an academic health system, USA Health is on the forefront of cancer research and treatment. For molecular test inquiries, contact the Molecular Pathology Lab at (251) 471-7335 or by email at molecularlab@health.southalabama.edu.

Tuesday, November 9, 2021

Faculty Spotlight: Richard Menger, M.D., M.P.A.

Richard Menger, M.D., M.P.A. 

Academic title: Director of the USA Health Spine Institute, assistant professor of neurosurgery, assistant professor of political science  

Joined the USA College of Medicine: 2019 

What does your position in the USA COM/USA Health entail?
I am part of the neurosurgery faculty with a focus on complex spinal disorders for things like scoliosis, kyphosis, and revision spine surgery. I perform the spectrum of spine surgery from minimally invasive CT-navigated procedures to spine reconstruction surgery. My research focuses on spine surgery techniques, surgical outcomes, and then also on the policy and economics of healthcare. 

What is your favorite or most rewarding part of your position?
Treating people with complex problems is very rewarding. Many of my patients have had multiple consultations and previous surgeries, and our whole team can make such a substantial impact in their life. 

What is your advice for medical students?
Specialize in whatever excites you the most and get after it. If you truly feel called to do something and truly enjoy it, you will be motivated to keep learning and striving to be the best at it. Always seek to learn new things and embrace being uncomfortable because it means you are pushing your boundaries, growing and learning.    

What are your hobbies/interests outside of work?
Spending as much time as possible with my family and being out on the water/on the beach. 



Meet a Med Student: Christian Manganti

Christian Manganti

Age: 24

Class of: 2024

Hometown: Gulfport, Miss.

Undergrad/grad institution: University of South Alabama

Degrees earned: Bachelor of Science in Biomedical Sciences

Interests, hobbies: I love to cook, and I try to go to the gym when I have time.

Something unique about me: I have two jobs! I’m blessed that I get to work in the specialty pharmacy at USA Health’s Mitchell Cancer Institute, and I tutor high school students.

Three of my favorite things: A good meal, spending time with my girlfriend and a successful Costco trip.

What I enjoy most about being a student at the USA College of Medicine: I love our sense of community! I have never felt a competitive energy. Everyone is so kind, and we try to help each other when we can with whatever we can.



Friday, November 5, 2021

Video online: 'Emerging Trends in Radiation for Breast Cancer'

Robert Gilbert, M.D., a radiation oncologist at the USA Health Mitchell Cancer Institute and assistant professor of interdisciplinary clinical oncology at the USA College of Medicine, presented “Emerging Trends in Radiation for Breast Cancer,” at the Med School Café lecture on Oct. 28.

Watch a video of video of the presentation on YouTube or below.

Williams presents on COVID-19 vaccine hesitancy at national meeting

Jacob Williams, third from left, presented at the American Public
Health Association's national meeting in Denver. He is shown
with the session's moderator and fellow presenters. 
Jacob Williams, a third-year medical student at the USA College of Medicine, recently gave an oral presentation at the American Public Health Association's national annual conference in Denver. He discussed findings from a recent study examining public trust in sources of pandemic information and COVID-19 vaccine hesitancy. 

“Vaccine hesitancy has been a hot topic lately with the development of COVID-19 vaccines, so I, and the rest of my great research team, wanted to see where people of Alabama were getting their pandemic information,” Williams said. “We wanted to see if trust in certain media sources would correlate with intention to receive the vaccine.” 

In November 2020, 3,781 participants were recruited for the study through Facebook advertisements that linked to a 15-minute survey. Participants were Alabama residents over 18 years of age. The study was funded, in part, by the Immunization Division of the Alabama Department of Public Health. It was part of a larger data project by Casey Daniel, Ph.D. M.P.H., associate professor of family medicine and director of epidemiology and public health at USA Health. 

Other members of the research team were Rachel Legg, Pharm.D., clinical pharmacist in family medicine; Chelsea Green, M.P.H., research coordinator at the Mitchell Cancer Institute; and Jesse Stutzman, M.P.H., a third-year medical student. 

“Our goal with our abstract was to present information that could then lead to development of a strategy to increase public trust in sources of pandemic information, ultimately increasing vaccine uptake,” Williams said. 

The study found that among those with no intent to vaccinate, 75 to 89 percent reported complete distrust of major news outlets and social media (Facebook and Twitter), with 42 to 48 percent reporting distrust of local health departments and the Center for Disease Control and Prevention. Among this same population, the only sources with a majority reporting “mostly or complete” trust were healthcare providers (50 percent) and then-President Donald Trump (51 percent).

“These high levels of distrust for major sources of pandemic information among individuals not intending to get the COVID-19 vaccine highlight the necessity of a multifaceted approach to distribute factual information,” the study concluded. “Public health strategies should take into account how personal biases against particular media may adversely affect the impact of educational approaches. Maintaining consistent vaccination messaging, grounded in science, across all information sources will minimize conflict between these sources and mitigate bias regarding COVID-19 vaccination as well as vaccination decisions for future public health crises.”

Estrada recognized by Sun Belt Conference for pandemic collaboration

Sun Belt Conference Commissioner Keith Gill, left, recognizes
Benjamin Estrada, M.D., pediatric infectious diseases specialist
at USA Health and professor and vice chair of pediatrics at the
USA College of Medicine.  
USA Health pediatric infectious diseases specialist Benjamin Estrada, M.D., was recognized by the Sun Belt Conference for his efforts on COVID-19 protocols during an annual meeting on Nov. 2 in Atlanta.

The collaboration between Estrada and other healthcare faculty from across the conference is credited with allowing athletic programs to continue and giving college athletes the opportunity to more safely compete during much of the global health pandemic.

“We’re proud of the hard work and accomplishments of all of our 2020-21 honorees and we were delighted to be able to celebrate their achievements in person,” said Sun Belt Conference Commissioner Keith Gill. “We were pleased, too, to recognize the members of our COVID-19 advisory panel for their work, enabling us to safely compete throughout the 2020-21 season.” The Sun Belt Conference COVID-19 panel included Estrada; Brandy Clouse of Georgia Southern; Jeff Dugas, M.D., of Troy; and Emilio Carranco, M.D., of Texas State.

Estrada is assistant dean for educational strategies and faculty development, and professor and vice chair of pediatrics at the USA College of Medicine.

Wednesday, November 3, 2021

Mitchell Cancer Institute’s colon cancer research featured in national journal

Kevin Lee, Ph.D., assistant professor of research, works in a lab at the Mitchell Cancer Institute.
A compound discovered at the USA Health Mitchell Cancer Institute has been shown to block an enzyme critical to the development of colon cancer in mice and is the subject of a new paper published in the scientific journal Cancer Prevention Research.

The compound, ADT 061, is a derivative of the non-steroidal anti-inflammatory drug sulindac and was developed in-house at the MCI, said Kevin Lee, Ph.D., assistant professor of research and lead author of the paper, featured on the cover of the journal’s November issue.

Mitchell Cancer Institute researchers treated mice with ADT 061 to determine whether it would inhibit the enzyme phosphodiesterase 10A (PDE10), which is overexpressed in colon cells during the early stages of cancer and is essential for colon cancer cell growth. MCI collaborated with Fox Chase Cancer Center in Philadelphia on the project.

“We found that ADT 061 inhibits colon cancer cell lines without inhibiting normal cell lines,” Lee said. “In the mouse model with a high incidence of colon cancer, we saw a 30 to 40 percent decrease in cancer.”

Lee said that while some anti-inflammatory drugs produce toxic side effects in the liver, ADT 061 was modified to have fewer side effects. He said that further studies in animal models will be needed to test the compound for safety and efficacy.

ADT 061 was among two classes of anti-cancer compounds discovered in recent years by former MCI researcher Gary A. Piazza, Ph.D., now at Auburn University, and MCI’s Drug Discovery Research Center. Their development as potential drug candidates for colon, pancreatic and gynecologic cancers have been the subject of research presentations and awards over the past three years.

Read the full article in Cancer Prevention Research

Faculty Spotlight: Daniel McMahon, M.D.

Daniel McMahon, M.D.

Academic title: General surgeon and assistant professor of surgery

Joined the USA College of Medicine faculty: August 2020

What does your position in the USA COM/USA Health entail?
Comprehensive care of the surgical patient to include operating room cases, seeing patients in the office, seeing patients in the hospital, and teaching/instructing medical students and surgical residents. 

What is your favorite or most rewarding part of your position?
Taking care of sick patients and seeing them recover as well as teaching the medical students and residents. 

What is your advice for medical students?
Work hard, take it one day at a time, and pursue a medical specialty you truly find fascinating and rewarding.

What are your hobbies/interests outside of work? Hunting, fishing and traveling


Tuesday, November 2, 2021

Carpenter recognized for top academic performance

Christopher Davies, Ph.D., professor of biochemistry and
microbiology and associate dean for research at the USA 
College of Medicine, presents Chelsie Carpenter with the
Edwin R. Hughes Memorial Award.
Chelsie Carpenter, a second-year student in the Basic Medical Sciences Graduate Program at the USA College of Medicine, is the recipient of the Edwin R. Hughes Memorial Award for the 2020-2021 academic year. The award recognizes the student with the best academic performance in the program’s core curriculum.

Carpenter is in the Cell and Molecular Biology track. She works in the lab with Mark Swingle, Ph.D., associate professor of biochemistry and molecular biology, studying a rare neurological disorder called Jordan’s syndrome. Her research is focused on RNA-binding proteins and the cytoskeleton structure, particularly actin and proteins bound to it. 

“My experience in the BMS program has been great!” Carpenter said. “All the professors pretty much have an ‘open door’ policy, so they are all very welcoming and eager to help students and answer questions. I feel so welcomed and comfortable in our building and program.” 

Carpenter earned a Bachelor of Science in biology from the University of North Carolina - Wilmington.

The award is named in memory of Edwin R. Hughes, who served as director of the Basic Medical Sciences Graduate Program at the USA College of Medicine from its inception in 1978 until 1990.

Trauma surgeon and youth advocate joins surgery faculty

With an emphasis on promoting community wellness, Ashley Williams, M.D., joined USA Health as a critical care surgeon at University Hospital and as an assistant professor of surgery at the USA College of Medicine.

Williams moved to Mobile in 2015 to complete a residency at USA Health’s University Hospital. During that time, she helped develop Project Inspire, a mentorship program for youth in the Mobile area who had early encounters with the juvenile justice system. Williams co-founded Project Inspire with Jon Simmons, M.D., chief of trauma and acute care surgery at USA Health. The program’s goal is to provide its young participants with positive influences and learning experiences to set them on a path to brighter futures.

Williams was compelled to develop Project Inspire after noticing that many patients who received trauma care were alarmingly young victims of violence. She began to imagine ways to promote safety and ambition among teenagers.

“I wanted to not only deter kids from making poor decisions, but also inspire them to be the best version of themselves,” said Williams. “A lot of kids might not be able to see the world, but as members of the community, it’s our job to bring the world to them and show them their full potential.”

After Williams completed her surgical residency, Simmons reached out to her about an open position at USA Health. Since returning, Williams has begun working on a new aspect of the youth program that allows all interested teenagers to participate in the curriculum.

“Project Inspire originally started with kids who were at Strickland Youth Center for gun-related offenses,” said Williams. “It wasn’t long before we had parents and grandparents reaching out for their children to join the program. So, we’ve been working on more comprehensive curriculum that allows all teenagers to join.”

While Project Inspire’s potential expansion played a large role in Williams’ decision to return, the family she cultivated at USA Health also was a determining factor. Her husband, Antwan Hogue, M.D., is a Mobile native, a hospitalist and assistant professor of internal medicine at University Hospital.

“I really enjoyed the entire surgery department here during my residency,” Williams said. “I definitely had no reservations about coming back.”

Williams grew up in Augusta, Ga. She earned a Bachelor of Science degree in microbiology from the University of Georgia in 2011. That year, she began a doctorate program at the University of South Carolina School of Medicine Columbia with intentions to pursue cardiology.

A mission trip to Liberia during her first summer of medical school inspired Williams to shift her focus to surgery. She became fascinated with the dynamic, fast-paced environment of the operating room and the immediate gratification that came from remedying patient issues.

“That mission trip was my first exposure to the operating room,” she said. “I was able to see patients come in with a problem, go to the operating room, and come out with their problem fixed. It felt like a field where you could help someone through their most vulnerable state and impact their life for the better.”

After completing medical school in 2015, Williams relocated to Mobile for a general surgery residency at University Hospital. She completed the residency in 2020, then moved to the University of Pittsburgh Medical Center to complete a surgical critical care fellowship. She returned to University Hospital this fall.

Thakur to discuss 'Skull Base Neurosurgery and Brain Tumors' at Med School Café

“Skull Base Neurosurgery and Brain Tumors: Rejecting Norms and Adapting Minimally Invasive Mentality” will be the topic of a Med School Café presentation at 10 a.m. Friday, Nov. 12. Jai Thakur, M.D., director of minimally invasive cranial and skull base neurosurgery and neurosurgery education at USA Health, will present the lecture via Zoom.

Thakur, an assistant professor of neurosurgery at the USA College of Medicine, is a fellowship-trained neurosurgeon who specializes in the field of endoscopic and minimally invasive keyhole cranial surgery. His focus is caring for patients with brain tumors (including pituitary tumors, skull base tumors, primary/metastatic tumors) and cerebrovascular diseases like aneurysm, vascular malformations, sickle cell disease and Moyamoya disease, which potentially can cause strokes. Additionally, he specializes in managing medically refractory facial pain/trigeminal neuralgia, hemi-facial spasms and spontaneous skull base CSF leaks.

After graduating from medical school at Government Medical College in Amritsar, India, he completed a two-year research fellowship in skull base neurosurgery at Louisiana State University (LSU) and University of Arkansas Medical Sciences, followed by residency training in neurosurgery at LSU. He then completed fellowship training in minimally invasive cranial and skull base neurosurgery at the Pacific Neuroscience Institute-John Wayne Cancer Institute in Santa Monica, California.

Register here to attend the lecture virtually

Med School Café is a free community lecture series sponsored by USA Health. Each month, faculty and physicians share their expertise on a specific medical condition, providing insight on the latest treatments available.

For more information, contact Kim Partridge at kepartridge@health.southalabama.edu.

Meet a Med Student: Lita Araysi

Lita Araysi

Age: 26

Class of: 2023

Hometown: Chicago

Undergrad/grad institution: The University of Chicago

Degrees earned: Bachelor of Science in biochemistry, Bachelor of Arts in chemistry

Interests, hobbies: Traveling, attending concerts, attempting to play piano by learning only parts of random songs and binging shows that I clearly don't have time for.

Something unique about me: My first word as a baby was the Arabic word "tai," meaning "come." I tore my ACL in the final two soccer games of the season during my senior year of high school and left with a (subjectively cool?) scar from reconstructive surgery.

Three of my favorite things: Trying new restaurants/cuisine, my cat Leo, family/friends

What I enjoy most about being a student at the USA College of Medicine: No doubt the people. From classmates, to faculty, to residents and attendings at University Hospital, people have been nothing but welcoming and supportive!