Friday, February 17, 2023

Inabnet to present Fazier/Leigh Memorial Lectures

William B. Inabnet, M.D., M.H.A., professor and chair of the department of surgery at the University of Kentucky College of Medicine, will present two CME-accredited lectures as part of the Emmett B. Frazer, M.D./Milton M. Leigh M.D. Endowed Memorial Lectureship at the University of South Alabama. 

Inabnet will present his first lecture, “Leadership in Academic Surgery,” at 4:30 p.m. Thursday, Feb. 23,  in the Strada Patient Center conference room and via Zoom. Join the lecture

His second lecture, “Advances in Endocrine Surgery: Disease Management, Technology and Surgical Technique,” will be presented at 7 a.m. Friday, Feb. 24, in the second-floor conference room at USA Health University Hospital and via Zoom. Join the lecture

For more information on both lectures, contact the department of surgery at 251-445-8230.

Faculty development to focus on conflict resolution

In the month of March, the Whiddon College of Medicine's Office of Faculty Development is focusing on the theme of conflict resolution. 

Jeanne Maes, Ph.D., professor of management at the University of South Alabama, will address dealing with conflict at work at the faculty development grand rounds on Friday, March 3, at noon via Zoom. One CME credit will be provided. Register for the session.

Maes suggests watching these videos on the topic:

The following books have been purchased by the department and are available on loan to faculty and staff:

  • "Never Split the Difference," Chris Voss
  • "Getting More: How You Can Negotiate to Succeed in Work and Life," Stuart Diamond

Other faculty development programs in March:

Kognito Training with Binata Mukherjee, M.D., M.B.A.
March 14, noon to 2 p.m. (lunch provided)
Strada Patient Care Center, first floor conference room
1.5 CME credits, limited to 25 participants
Register for the training session.

Scholarship of Teaching & Learning Workshop
Introduction of AAMC's MERC Program with David Williams, Ph.D., and Emily Wilson, Ph.D. 
March 14, 2 to 4 p.m.
Strada Patient Care Center, first floor conference room

Teaching kitchen provides hands-on culinary medicine experience for medical students

Fourth-year medical students take part in a hands-on course in culinary medicine at the teaching kitchen in University Commons.

By Michelle Ryan

Being advised to eat healthy and get exercise by physicians is common, but often is too vague to be effective. A recently added health and wellness elective for fourth-year medical students aims to change that; and this semester, it got a significant practical boost.

David Weber, Ph.D., assistant dean for medical education and professor of physiology and cell biology at the Frederick P. Whiddon College of Medicine, taught the four-week culinary medicine portion of the course for the first time in the three years it has been offered at the teaching kitchen. Located in University Commons, the kitchen is part of USA Health’s Integrative Health and Wellness Program.

“The overall focus of the course for students is to learn ‘walking around’ (practical) knowledge about nutrition, fitness/exercise and wellness/mindfulness so that they are capable of discussing these topics with their future patients,” he said. “This availability of the teaching kitchen in collaboration with USA Health's Integrative Health and Wellness has allowed us to engage our students at a much deeper level with the concept that food is medicine.”

Given that nearly 75 percent of Americans are overweight and eight of 10 deaths are lifestyle-related, according to the Centers for Disease Control and Prevention, changing behaviors about food, exercise and wellness is critical. 

David Weber, Ph.D., left, and Robert Israel, M.D., lead a
class discussion on how nutrition impacts patient wellness
and outcomes. 
Many medical schools offer 25 course hours or less in nutrition over four years, according to a study in The Lancet Planetary Health. Classes like Weber’s and the practical knowledge they provide are just as important to prepare future physicians like Magnolia McElyea.

“It really was integral to the class as far as retaining information from our readings and seeing hands-on how to incorporate the nutritional concepts into everyday meal prep,” McElyea said of the teaching kitchen environment. “We were able to see what meals high in protein, veggies or grains would look and taste like.”

In the kitchen classroom, the fourth-year medical students traded textbooks and pens for cutting boards and pans as they learned about the impact of healthy diets on patient wellness and outcomes. Specifically, they focused on making better choices in carbohydrates, proteins and fats, and they were tasked with making a meal applying what they learned each week.

“Our goal is that as our future physicians, they apply this knowledge in residency and practice, so that our impact extends much further than just a single medical school course,” Weber said. 

One of the first impacts the course has is often on the students themselves. According to Weber, they are introduced to important skills like basic meal preparation, how to read labels to identify wholesome options, and learning that healthy food can taste great and be affordable. 

“The teaching kitchen is tremendously valuable in that it takes the discussion and science of ‘healthy eating’ and connects it to what this looks like in the real world to make great, tasty and flavorful meals,” he said. “Anecdotally, it seems that most students become much more aware of their own diets and how they navigate the grocery store while taking this course.”

The course, Applications of Health and Wellness Strategies, doesn’t end with the work in the kitchen. Additionally, students are adopting exercise and stress management habits, tracking their progress and evaluating their experience with the intention of relating better to their future patients.

“In the application phase, students are challenged to design systems to implement and track one or more changes in these areas for themselves during the course to appreciate how challenging lifestyle modifications can be for everyone,” he said. 

Weber said that even a basic understanding of nutrition, exercise and stress management, as well as the students’ application of the concepts, will spark a more meaningful discussion with patients instead of simply offering vague advice. 

“Appreciating the benefits of maintaining a healthy lifestyle, as well as the associated obstacles that challenge many of us, allows the physician to relate to the patient and meet them where they are, help in goal setting, and empower them in the process of improving their overall health,” he said.

For the students, like Kasey Andrews, the teaching kitchen space helped accomplish two important things.

“Overall, the use of the culinary kitchen was not only a fun way to bond with classmates over food,” she said, “but it also allowed me to grow my interest and knowledge in culinary medicine in a way that I truly believe will allow me to provide better and more complete advice to patients and their families in the future.” 

Nearly 50 universities, medical schools, healthcare systems and community organizations utilize a teaching kitchen space like USA Health’s with the goal of encouraging people to make healthier choices by allowing them to put what they learn into action.

David M. Eisenberg, M.D., an American physician, alternative medicine researcher and the Bernard Osher Distinguished Associate Professor of Medicine at Harvard Medical School, proposed the concept of a teaching kitchen in 1998, and the Teaching Kitchen Collaborative was established under his leadership in 2016.

Prior to its establishment, a study tracking participants who had hands-on experience in teaching kitchens found sustained decreases in blood pressure, weight, waist circumference and fat levels, according to Global Advances in Integrative Medicine and Health, a journal that shares evidence-based research and knowledge about multidisciplinary therapeutic approaches and lifestyle practices that promote whole-person health.

Additional clinical trials at the Cleveland Clinic, McGill University and Tulane University suggest that nutrition education coupled with hands-on instruction can make positive changes in medical indicators, like blood pressure, cholesterol, glucose levels and BMI, as well as in health outcomes. 

“Encouraging patients to make healthy lifestyle choices enables patients not only to live longer, but in my opinion, to experience a much higher quality of life by allowing them to continue engaging in the activities they enjoy,” Weber said. “Often, seemingly small lifestyle changes in the areas of diet, exercise or stress management can have a major impact in reducing chronic disease. Thus, applying an integrative approach to healthcare with patients has tremendous potential to slow disease progression, or better yet, prevent disease from occurring.”

Thursday, February 16, 2023

Menger invited to present at international symposium

Richard Menger, M.D., M.P.A., chief of complex spine surgery at USA Health, recently was invited to speak at the International Spine Deformity Symposium (ISDS) in New York City. This meeting focuses on scoliosis and spinal deformity in adults.

Menger presented research on spinal instrumentation. He discussed the safety of the freehand pedicle screw technique without the use of X-ray guidance, navigation or robotic surgery.

“The focus is on safety, efficiency and anatomy,” said Menger, assistant professor of neurosurgery at the Frederick P. Whiddon College of Medicine. “With over 1,800 pedicle screws placed, we were able to prove that our instrumentation complication rate was equal to or less than that of robotic or other expensive technology dependent techniques.”

The research began during the summer session in 2022 in collaboration with USA Health’s orthopaedics department and the help of Maxon Basset, medical student at the Whiddon College of Medicine, and Patrick Young, M.D., orthpaedics resident at USA Health.

“This research would not have been possible without the University of South Alabama’s commitment to research and funding through the Medical Student Research Program,” Menger said.

Learn more about the research.

Pierce presents talk on HPV, cervical cancer

Harnessing what we know about the human papillomavirus (HPV) will help us prevent and eliminate cervical cancer, USA Health gynecologic oncologist Jennifer Young Pierce, M.D., M.P.H., told hundreds of providers at a recent meeting of the Society of Gynecologic Oncology.

Pierce, leader of the division of cancer control and prevention at the USA Health Mitchell Cancer Institute, was invited to give the presentation at the SGO winter meeting held Feb. 2-4 in Whistler, British Columbia.

HPV infection is responsible for six types of cancers in men and women, including cervical, oropharyngeal, anal, penile, vaginal and vulvar cancer.

“In May 2018, the WHO director general announced a global call for action to eliminate cervical cancer,” said Pierce, who also is a professor of gynecologic oncology at the Frederick P. Whiddon College of Medicine. “This was the first time the world has committed to eliminating a cancer.”

Two years later, a global strategy was adopted that urged vaccinating 90% of girls with the HPV vaccine, screening 70% of women in their 40s and treating 90% of women with pre-cancer and invasive cancer. The goal: lowering the incidence of cervical cancer by 97% by 2120.

We still have a long way to go toward reaching that goal, Pierce said. Every year, 37,000 people in the U.S. are diagnosed with an HPV-related cancer. “That’s about one case every 20 minutes,” she said.

The HPV vaccine, introduced in 2006, has proven to be safe and effective, with about 350 million doses given around the world in more than 15 years, she said. A population-based study in Finland documented zero HPV cancers in women who were vaccinated against HPV. “HPV vaccination is safe. HPV vaccination works, and HPV vaccination lasts,” she said.

Current knowledge about HPV can inform how we screen women for cervical cancer. In recent years, providers have offered three screening options – primary HPV testing, the Pap test (cytology) and both screening methods used together.

Pierce said the HPV test should be used as the primary method of screening, an approach that is being adopted by health organizations, including the ASCCP, the American Society for Colposcopy and Cervical Pathology. “The Pap is a test developed in the 1940s and needs to be repeated frequently,” Pierce said. “An HPV test is a much better predictor of current and future risk for cervical cancer.”

Relying on HPV testing as the primary screening tool allows providers to assess the risk of cervical cancer for women, and the guidelines can be adjusted for decreasing risk as more vaccinated patients reach the age for screening, she said. Once screened, it’s important to follow up and treat cancers and pre-cancers according to ASCCP guidelines.

Pierce called on GYN oncologists and others to become advocates for this approach. “We need everyone to join the fight for HPV to be used for primary screening, which is more likely to find cancer earlier,” she said.

Wednesday, February 15, 2023

Solidarity Bingo winners announced for Solidarity Week

Happy Solidarity Week! The Gold Humanism Honor Society would like to thank everyone who participated in Solidarity Bingo as part of Wellness Wednesday and announce the raffle winners:

Student Winners

  • Payal Patel – gift certificate for a gel manicure at Lily’s Nails
  • Isabelle Hudson – $25 gift card to VOR Nutrition
  • Sam Thomas – gift certificate for two dozen doughnuts from Sugar Rush
  • Regan Shaw – gift certificate for one dozen doughnuts from Sugar Rush and phone selfie light
  • Ian Thompson – $25 gift card to Simple Greek

Faculty/Staff Winners

  • Amber Bokhari, M.D. – 10-inch bundt cake from Nothing Bundt Cakes and digital bookmark
  • Laura Boatright, M.D. – $25 gift card to Butch Cassidy’s

Please email an1221@jagmail.southalabama.edu to arrange the best time and place to pick up your items. Continue to provide compassionate care in celebration of Solidarity Week, every week! #solidarityweek

Save the date: USA Neuroscience Symposium

The eighth annual USA Neuroscience Symposium will be April 14-16 in Pensacola, Florida. This program provides an update on important topics in neurology and addresses clinical competencies of knowledge, performance and improving patient outcomes. 

This year’s symposium will feature lectures and roundtable discussions from the neurology faculty at the Frederick P. Whiddon College of Medicine and the following guest speakers:

  • Christopher H. Gottschalk, M.D., FAHS – professor of neurology at Yale School of Medicine, director of the Yale Headache and Facial Pain Program and the chief of the division of general neurology
  • James F. Howard, Jr., M.D., FAAN – professor of neurology, medicine and allied health at the University of North Carolina at Chapel Hill and director of the Mysathenia Gravis Clinical Trials and Translation Research Program
  • John Soltys, M.D. – fellow at the University of Oxford in Oxford, England
  • James Rini, M.D. – assistant professor of neurology at Ochsner Medical Center

All current and future healthcare professionals are invited to attend. Learn more about the event and register


Monday, February 13, 2023

Distinguished Scientists Seminar set for Feb. 16

The Frederick P. Whiddon College of Medicine's next Distinguished Scientist Seminar is set for 4 p.m. Thursday, Feb. 16, in the Medical Sciences Building first-floor auditorium and via Zoom. 

The speaker is Oliver McDonald, M.D., Ph.D., associate professor of pathology, director of gastrointestinal research, and director of the Pathology Physician Scientist Program at the University of Miami Miller School of Medicine. He will present “Adaptive Metabolism Reprograms Chromatin for Widespread Metastatic Outgrowth.”

The lecture, hosted by Glen Borchert, Ph.D., is sponsored by the Department of Pharmacology.

The Distinguished Scientists Seminar Program features talks given by leading scientists from outside institutions. Speakers are selected to complement the graduate training program in the Whiddon College of Medicine and cover a wide range of cutting-edge biomedical research. 

Watch the lecture via Zoom: https://southalabama.zoom.us/j/99901977833

USA researchers uncover novel mechanism that supports survival of pancreatic cancer cells

Shashi Anand, Ph.D., a postdoctoral researcher, is studying how pancreatic cancer cells adapt to live in low-oxygen environments.
Pancreatic tumors are notoriously aggressive and highly resistant to therapy, making pancreatic cancer the third leading cause of cancer-related death in the United States. With the goal of finding more successful treatment of the disease, researchers at the USA Health Mitchell Cancer Institute and the Frederick P. Whiddon College of Medicine at the University of South Alabama are examining how pancreatic cancer cells adapt to live under low-oxygen environments, a state known as hypoxia. 

Findings from their study, “MYB sustains hypoxic survival of pancreatic cancer cells by facilitating metabolic reprogramming,” were recently published in EMBO Reports, a high-impact journal that publishes scientific research in all areas of molecular biology. Shashi Anand, Ph.D., is the lead author of the article. Anand is a postdoctoral researcher in the lab of Ajay Singh, Ph.D., a professor of pathology at the Frederick P. Whiddon College of Medicine and leader of the Cancer Biology Program at the Mitchell Cancer Institute. 

The unique histopathology of pancreatic cancer, such as its highly fibrotic nature and poor vasculature, renders the cancer cells severely hypoxic – a major reason why these tumors are so aggressive and therapy resistant. Anand said their studies have found that MYB, a protein-coding gene, plays an essential role in the survival of pancreatic cancer cells under hypoxia. 

“We have found that MYB levels go up in hypoxic cancer cells and help cancer cells in reprogramming their metabolism to reduce dependency on oxygen,” Anand said. “Importantly, we also found that MYB affected the expression and function of hypoxia-inducible factor 1 alpha (HIF1α), a protein believed to be the master regulator of the hypoxia adaptive response in cells.” Research on HIF1α won the Nobel Prize in Medicine in 2019 due to its high significance in health and disease. 

“We noticed in our study that MYB was essential for full functionality of HIF1α,” Anand said. “When we silenced MYB expression in pancreatic cancer cells by genetic manipulation, they failed to form tumors in mice despite forced overexpression of the HIF1α protein.”

Their findings are significant since hypoxia is an inevitable environmental stress that tumor cells face as they evolve and progress. “Adaptive mechanisms that help cancer cells survive under hypoxia also make them more aggressive and resistant to chemotherapies,” Anand explained. “Thus, our findings expose novel therapeutic vulnerabilities that can be targeted for effective treatment of pancreatic cancer.” 

The work is supported by funding from the National Cancer Institute. Additional authors from the Mitchell Cancer Institute and the Whiddon College of Medicine are Mohammad Aslam Khan, Ph.D.; Haseeb Zubair, Ph.D.; Sarabjeet Kour Sudan, Ph.D.; Kunwar Somesh Vikramdeo, Ph.D.; Sachin Kumar Deshmukh, Ph.D.; Shafquat Azim, Ph.D.; Sanjeev Kumar Srivastava, Ph.D.; Seema Singh, Ph.D.; and Ajay Singh, Ph.D. 

Read the full article in EMBO Reports.