Friday, March 11, 2022

USA Health researcher to present on breast cancer disparities at national conference

Sarabjeet Kour Sudan, Ph.D., a postdoctoral research fellow, is studying why Black women are disproportionately affected by breast cancer.
Sarabjeet Kour Sudan, Ph.D., a postdoctoral research fellow at the USA Health Mitchell Cancer Institute and the department of pathology, will present her findings on breast cancer disparities at the American Association for Cancer Research (AACR) annual meeting, set for April 8-13, in New Orleans. 

Black women have earlier onset of breast cancer, are frequently diagnosed with aggressive triple-negative subtype, and have higher mortality rates when compared with white women. Although socioeconomic differences and access to healthcare have long been believed to be the underlying causes of such racial disparities, an interplay of social and biological factors might also play a role, Sudan said. 

“We hypothesize that socioeconomic hardships faced by African American women may alter their physiology through release of stress hormones,” she said. “Further, it may also affect their dietary choices and lifestyle behavior, leading to increased obesity and inflammation, thus putting them at higher risk of developing cancer.” 

To test their hypothesis, researchers analyzed more than 150 blood samples collected from Black and white women, with and without breast cancer diagnoses, who visited USA Health clinics in the past two to three years. They also collected their socioeconomic and stress exposure data through a survey.

“We found that African American women had higher levels of stress, obesity and inflammation-associated hormones and cytokines in their serum as compared to white women, regardless of their breast cancer diagnosis,” Sudan said. “Moreover, we found that the levels of these hormones and cytokines were increased in women with a breast cancer diagnosis relative to the non-cancer subjects.” 

In addition, researchers detected differential presence of certain microRNAs in the blood serum of Black women. In parallel studies, they have found that these microRNAs have immunosuppressive functions and promote the growth of breast cancer cells. 

“Our findings suggest a novel sociobiological link for the breast cancer disparities in African American women. These biological differences could be exploited for risk-prediction and to guide early interventions for minimizing the disparity gaps,” she said.

Sudan received a travel award from the Geographic Management of Cancer Health Disparities Program (GMaP) Region 2, funded by the National Cancer Institute, to attend the meeting. AACR is the world’s largest cancer research organization, and thousands of scientists from around the world attend the annual meeting. 

“Having an opportunity to share my findings with my peers and senior scientists will be a great experience,” she said. “It will allow me to build a network with other cancer disparity scientists, receive their feedback, and possibly develop new collaborations to widen my research scope.”

Sudan works in the lab with mentor Seema Singh, Ph.D., professor of pathology and a senior member of the Cancer Biology Program at the MCI, whose work is supported through a grant from the National Cancer Institute. 

Collaborators on the project are Lynn Dyess, M.D., a breast/endocrine surgeon and professor of surgery; Teja Poosarla, M.D., a former oncologist at the MCI; Nicolette Holliday, M.D., an obstetrician/gynecologist and associate professor of obstetrics and gynecology; Jennifer Young Pierce, M.D., M.P.H., a gynecologic oncologist, head of the Cancer Control and Prevention Program at the MCI, and professor of obstetrics and gynecology; Casey Daniel, Ph.D., M.P.H., director of epidemiology and public health, and associate professor of family medicine; and Ajay Singh, Ph.D., head of the Cancer Biology and Cancer Health Disparities Programs at the MCI and professor of pathology.

Sudan received her doctoral degree from CSIR-Institute of Microbial Technology in Chandigarh, India. She was the recipient of a senior research fellowship from DST-Innovation in Science Pursuit for Inspired Research (INSPIRE), a research agency in India.

Thursday, March 10, 2022

Meet a Med Student: Sidney Bailey

Sidney Bailey

Age: 23

Class of: 2025

Hometown: Monroeville, Ala.

Undergrad/grad institution: Auburn University

Degrees earned: Bachelor of Science in biomedical sciences

Interests, hobbies: Watching and playing a variety of sports, playing video games and spending quality time with friends and family.

Something unique about me: I was once selected to attend a national leadership conference held in Washington D.C. and had the opportunity to meet and interact with fellow students from all 49 other states.

Three of my favorite things: Mexican food, The Office and spending time at the beach.

What I enjoy most about being a student at the USA College of Medicine: I truly enjoy the cohesiveness of our medical school class. We all get along and have made it a priority to enjoy time together as a class outside of the classroom. I definitely believe that the friendships and relationships formed during our time here will last a lifetime.



Wednesday, March 9, 2022

Bassam presents on diabetic neuropathy at annual meeting

Bassam Bassam, M.D., professor of neurology at the USA College of Medicine and a neuromuscular neurologist at USA Health Neurology, recently presented at the 48th Annual Clinical Neurological Society of America (CNSA) meeting.

“I am thankful for the opportunity to have been asked to present during this meeting,” Bassam said. “The CNSA is a great organization to help medical professionals dedicated to neurosciences improve patient care.”

Bassam is a member of the Scientific Program Committee with CNSA and the organizer of the neuromuscular session of the meeting. His presentation, “Diabetic Neuropathy (CNP) Classification and Treatment Update,” was the final presentation of the meeting.

He also was invited to address the “Meet the Professor” session after his presentation where he answered neuromuscular and clinical questions from the attendees.

Bassam is frequently asked to speak at national professional organizations of neurology annual meetings including the CNSA and the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM). 

View Bassam’s presentation here.

Tuesday, March 8, 2022

Poverty and public health: Arrieta works to reduce health disparities

At the USA Center for Healthy Communities, Martha Arrieta, M.D., Ph.D., M.P.H., has spent nearly 20 years working to reduce health disparities in poor and underserved neighborhoods of Mobile.
From the beginning, the USA Center for Healthy Communities has focused on neighborhood engagement, local partnerships and participatory research.

From the beginning, the center’s researchers and advocates have worked to build lasting relationships in poor and underserved neighborhoods.

From the beginning, Martha Arrieta, M.D., Ph.D., M.P.H., has been the center’s associate director, and then director of research.

The Center for Healthy Communities, often funded by grants from the National Institutes of Health, coordinates public education, improves access to healthcare, and promotes activities designed to eliminate health disparities in minority communities. According to the Centers for Disease Control and Prevention, Black residents of the United States are at a higher risk for heart disease, strokes and cancer, along with asthma, pneumonia and diabetes, though deaths from some major causes have declined by more than 25 percent over the last two decades.

Attitudes toward public health have changed since the Mobile center was founded in 2003.

“We can talk about the social determinants of healthcare and wellbeing, which was not always the case when I first came here,” said Arrieta, who also is associate professor of internal medicine at the USA College of Medicine. “We have come a long way in understanding that poverty is a major factor in public health. Another difference, and it is a painful difference, is the added burden of racism and structural elements that don’t allow people to rise up.

“We haven’t changed the world, but we have done steady work that contributes to making things better in the communities we serve. I’m very proud of what we’re doing.”

In January, the center and the Mobile County Health Department announced a partnership to increase the number of community health workers. This effort is part of a national initiative by the Centers for Disease Control and Prevention. It broadens the work of the center’s Health Advocates Program, in which community residents provide outreach and education.

“Because we’ve been here for 18 years, 19 years, people know who we are,” Arrieta said. “They have more trust in what we have to offer.”

In the first months of the coronavirus pandemic, the Center for Healthy Communities worked with neighborhood leaders to encourage mask-wearing and vaccination of adults, particularly older residents. Local pastors made public statements in favor of COVID-19 vaccinations.

“They really took a bold step to put their names and faces to this effort,” Arrieta said. “You know, it’s not been easy to be upfront, to be a vaccine supporter in Alabama and other parts of the country. But at the same time we understood that they were the ones officiating at funerals, so for them, this was extremely personal, and they came forward.”

Community relationships

Errol Crook, M.D., director of the Center for Healthy Communities, joined the USA Health program in 2005, just two years after it opened.

“Dr. Arrieta is the only person who’s been here since the inauguration of the center,” said Crook, who also is professor and chair of internal medicine at the USA College of Medicine. “So she’s been a real foundation and helped our work remain community-focused. She was very innovative in the early days of developing these relationships in the community.”

Bobbie Holt-Ragler, a retired nurse from Prichard, Alabama, has worked as a health advocate in Mobile for more than a decade. She understands that building trust takes time. The Center for Healthy Communities has earned its reputation with church groups, school leaders and civic organizations.

“This group has a heart,” said Holt-Ragler. “You just can’t find better folks. And they’re committed to the community. People don’t want to know how much you know until they learn how much you care.”

Mary Carmen Williams, outreach coordinator at the Center for Health Communities, works with Arrieta at the center office on North Catherine Street. She has led programs such as STARS and STRIPES, which help prepare high school students from under-represented communities for careers in science and medicine.

During the summer, students take classes at the University of South Alabama.

“Having them on campus is a big deal,” Williams said. “If we can help expose them to new things, it’s really rewarding.”

From Florida to Alabama

Arrieta, 64, is from Arequipa, the second largest city in Peru, which she visits each year for Christmas. Her father was a government worker and union leader, while her mother was a clerk and a seamstress. Her sisters include a teacher, a principal and a philosophy professor.

She earned her Ph.D. in epidemiology at the University of South Florida in Tampa. Her husband, Eduardo Calderon, M.D., is an associate professor of internal medicine at the USA College of Medicine and an infectious diseases physician with USA Health. They have a son, who is a doctoral student, and a daughter, who is an artist.

When she was in Florida, Arrieta worked with communities of migrant workers who picked oranges. Occupational health was an issue. So was poverty, access to healthcare and language barriers.

“I identified very much with them,” she said. “To me, it was a privilege to work for them. They’re doing very difficult work, they’re feeding America.”

Arrieta and her husband moved to Mobile in 1998, when he started his residency training in internal medicine at the University of South Alabama. Initially, Arrieta continued her work as research faculty at the University of South Florida, traveling to Tampa frequently both to teach and to complete her research program. In 2003, she began her work as faculty in the College of Medicine and also worked for the Mobile County Board of Health, where she was a consultant for surveillance and bioterrorism in the early 2000s.

At South, she teaches epidemiology and biostatistics to first- and second-year medical students. Coursework includes basic research tools and how to evaluate relevant literature.

In 2021, Arrieta wrote a report about how minority communities in Mobile were affected by the coronavirus. It was called “Perceptions, Needs, Challenges and Insights of an Underserved Community in the COVID-19 Pandemic.” It found families with fewer resources were impacted by four main stressors: increased childcare needs, added responsibility of remote education, economic peril due to job loss, and strained mental health and disrupted social network connections because of isolation and social distancing measures.

Reducing poverty and improving public health have proved to be difficult goals that resist simple solutions. Arrieta shares the frustration of many in her field. Experience has changed her perspective.

“When I was younger, I hoped things could change much faster, but I’m still hopeful,” she said. “Now that I’m older, I realize things usually change little by little.”

Arrieta still loves her job. She enjoys going to work very early in the morning, then leaving in the late afternoon. There’s always more to do.

“This is my passion,” she said. “I know I will retire one day, but I think I’d like to keep working in some capacity with this community.”

This story is part of a series by the University of South Alabama that focuses on USA students, employees and alumni who are advancing Dr. Martin Luther King Jr.’s vision in six areas – poverty, jobs and wages, housing, education, justice and peace. View the original story on the USA website

Gulf Coast Trauma Symposium set for March 24-25

The management of toxic stress and PTSD for patients and healthcare providers will be the focus of the 11th Annual Gulf Coast Trauma Symposium, set for Thursday and Friday, March 24-25, at the Battle House Renaissance Hotel & Spa in downtown Mobile.

It is presented by USA Health’s Division of Trauma, Acute Care Surgery and Burns in conjunction with Alabama Gulf EMS System.

The conference will be headlined by Eileen Bulger, M.D., as the 13th William A. L. Mitchell Lectureship speaker. Bulger is chair of the American College of Surgeons Committee on Trauma and the trauma medical director at Harborview Medical Center in Seattle. She is a national leader on violence prevention and pre-hospital care for injured patients.

“We believe one of the biggest gaps of knowledge/treatment from trauma centers across America is the lack of awareness of the prevalence of PTSD in our patients,” said Jon Simmons, M.D., chief of trauma and acute care surgery at USA Health. “We are very good at repairing organs and broken bones, but do not consider the emotional toll that is experienced over the remaining lifetime by the patient and caregiver.”

Over the past several years, USA Health’s trauma division has developed a pathway for the recognition and subsequent treatment of PTSD after severe injury. “One of the biggest goals for this conference is highlighting the importance of PTSD to the providers in our region,” Simmons said.

The second John Campbell Tribute lecture will be presented by Jeff Kerby, M.D., Ph.D., chief of acute care surgery and trauma medical director at the University of Alabama at Birmingham.

In addition, Heather Martin will join the symposium as a featured speaker about “Surviving Columbine: Lessons Learned in Survivor Care and Recovery.” Martin was two days away from her 18th birthday when the shooting occurred during her senior year at Columbine High School on April 20, 1999. After barricading in a small office for three hours, she returned home physically uninjured, but the effects of the trauma continued to impact her as she went off to college. Although the trauma caused her to drop out initially, she re-enrolled 10 years later and obtained a bachelor’s degree in English and a teaching license.

Martin co-founded The Rebels Project with fellow Columbine alumni after the shooting at the Aurora, Colorado, movie theater. Now an English teacher in Aurora, she is a national speaker advocating for informed responses to traumatic events from the perspective of a survivor.

Symposium breakout sessions will cover EMS and trauma nursing sessions.

Register here for the symposium.

In addition, there will be an Advanced Burn Life Support (ABLS) course will be held March 23, with a limited class size and separate registration. Sign up for the ABLS course here.

For more information, contact Rebecca Scarbrough at rscarbrough@health.southalabama.edu or 251-471-7971.

Monday, March 7, 2022

Nephrologist Abayomi Sanusi, M.D., joins internal medicine faculty

USA Health is expanding its team of specialized physicians with nephrologist Abayomi Sanusi, M.D., who diagnoses, treats and manages diseases that impact the kidneys. He also is an assistant professor of internal medicine at the USA College of Medicine.

Sanusi received his medical degree from the University of Lagos College of Medicine in Lagos, Nigeria. The practice of nephrology initially piqued Sanusi’s interest while he was in medical school, so he later moved to the United States to receive advanced training.

Sanusi worked as a medical officer in Nigeria for four years before moving to the United States in 1992 to start an internal medicine residency at Harlem Hospital Medical Center in New York. Then, he spent 11 years working at hospitals and clinics across the southern United States before returning to New York to pursue a nephrology fellowship.

He completed a fellowship at the University of New York Downstate Medical Center in Brooklyn in 2019. Most recently, he worked at Montgomery Kidney Specialists in Montgomery, Alabama. He is certified by the Nephrology Board of the American Board of Internal Medicine.

Sanusi sees patients at Mastin Internal Medicine. Call 251-470-5890 to make an appointment.

Pathology seminar series set for March 17

Lan Zhou, M.D., Ph.D., vice chair for research in the Department of Pathology at Case Western Reserve University School of Medicine, is the guest speaker for the USA Department of Pathology's upcoming Research Seminar Series.

She will present "Targeting CRABP-II/JAG1 Axis in Pancreatic Cancer Drug-Resistance and Immune Suppression" at noon on Thursday, March 17, in the Strada Patient Care Center conference room. Lunch will be served.

For more information, contact Patrick Carlisle at 251-471-7753 or pcarlisle@health.southalabama.edu